(Unflavoured) ACTIVJointRX Total Joint Support - Tendons, Ligaments & Cartilage
ACTIVJointRX contains a unique combination of 5000mg TENDOFORTE® and 5000mg FORTIGEL® Collagen Peptides. ★ TENDOFORTE®:Increase health and quality of ligaments and tendons, for active people involved in high-performance and flexible activities. Clinical trials have proven that when combined with physical activity, TENDOFORTE® decreases the risk of injury and improve flexibility. ★ FORTIGEL®:Regenerates...
ACTIVJointRX contains a unique combination of 5000mg TENDOFORTE® and 5000mg FORTIGEL® Collagen Peptides.
Increase health and quality of ligaments and tendons, for active people involved in high-performance and flexible activities. Clinical trials have proven that when combined with physical activity, TENDOFORTE® decreases the risk of injury and improve flexibility.
Regenerates joint cartilage, helping to ease joint discomfort. FORTIGEL® is clinically proven in numerous studies to increase cartilage regeneration and reduce joint pain, enabling people to maintain a physically active lifestyle.
More advanced and powerful form of Vitamin C, which is 100% bioavailable. Furthermore, Nutra-C®’s pH-neutral nature does not cause digestive problems.
TENDONS AND LIGAMENTS DETERMINE MOBILITY
Strong tendons and ligaments are crucial for lifelong wellness and physical activity. Ligaments bind bones together and tendons bind muscle to bone. Made of collagen, they are the connecting elements of the body, crucial for movement control, stability, and better mobility.
TENDOFORTE®, specific Bioactive Collagen Peptides (BCP®) from GELITA, is designed to increase the health and quality of ligaments and tendons. Pre-clinical and clinical trials show the positive effects of TENDOFORTE®, especially when combined with physical activity. The risk of injury decreases considerably, whilst flexibility improves. TENDOFORTE® significantly strengthens tendons and ligaments and more studies are underway.
TENDOFORTE® IS AN EFFECTIVE NUTRITIONAL INTERVENTION FOR STRONG TENDONS AND LIGAMENTS
Significant expression of extracellular matrix molecules with Bioactive Collagen Peptides (BCP®)
Schunck and Oesser, 2013.
Strong tendons and ligaments contribute to the foundation of high physical performance and fast return to training in athletes. They are also the prerequisite for the fluid and flowing motion required in isometric, high-flexibility exercises, such as yoga and Pilates. The strength of tendons and ligaments depends on an intact composition of the extracellular matrix collagens, proteoglycans, and elastic fibers. TENDOFORTE® is a Bioactive Collagen Peptide, optimized to stimulate the biosynthesis of new extracellular matrix molecules for healthy tendons and ligaments.
TENDOFORTE® BENEFITS THE BIOSYNTHESIS OF MATRIX MOLECULES OF TENDONS AND LIGAMENTS
A first experiment in-vitro observed that Fibroblasts, obtained from human ligaments and Achilles tendons, were able to produce significantly more tissue matrix (1.2 to 2.4-fold) when directly exposed to the Bioactive Collagen Peptides found in TENDOFORTE®. The RNA expression of collagen significantly increased, and the synthesis of elastin - the most prominent component of the ligament matrix - increased by approximately 50%. The breakdown of tissue was also reduced. This was the first study to suggest a role for Bioactive Collagen Peptides in reducing the risk of injuries and rupture of ligaments and tendons.
TENDOFORTE® IMPROVES THE EXTENSION PROPERTIES OF THE FINGER JOINTS
In one of the first clinical trials to look at a nutritional intervention for connective tissue weaknesses, the oral ingestion of specific collagen peptides was shown to improve the extension properties of the finger joints, due to firmer ligaments.
Proven improvements in mechanical stability of finger ligaments
Weh and Petau, 2001.
RECENT STUDY SHOWS THE EFFICACY OF TENDOFORTE®
A study by the Australian Institute of Sport (AIS) examined the benefits of TENDOFORTE® supplementation over a period of 6 months (cross-over design). The participants were 20 subjects with long-term symptoms of chronic Achilles tendinopathy, not responding to any traditional therapies, and being unable to train. Within 3 months, 12 out of 20 participants were able to return to running after starting therapy with a daily intake of 5 g TENDOFORTE® in combination with a highly specialized exercise program. Furthermore, the effect is long-term. The group starting with TENDOFORTE® in the cross-over design still had beneficial effects after the 3 months wash-out phase.
AIS Study - participants starting with TENDOFORTE® Supplementation returned to running, faster
South African Journal of Sports Medicine, 2017.
Reduced injuries due to improved ankle stability
In 2017, a randomized controlled study examined the effect of TENDOFORTE® on 60 men and women with ankle point instability over a period of 6 months. The daily intake of 5 g TENDOFORTE® showed a significant improvement in ankle stability during daily activity and during sports as well as significantly fewer injuries.
TENDOFORTE® provides connective strength
TENDOFORTE® is optimized to increase the health and quality of ligaments and tendons. The specific Bioactive Collagen Peptides® from GELITA address high-performance athletes and exercise enthusiasts as well as everybody having issues related to ligaments and tendons, such as CAI (chronic ankle instability), which often manifests after ankle sprains, one of the most widely spread sports injuries.
FORTIGEL® KEEPS PEOPLE PHYSICALLY ACTIVE AND MOBILE
Today, every fourth person suffers from joint problems and the number is constantly increasing. The principal cause is wear and tear of the joint cartilage brought about by age, over exercise, and stressed joints. But there is help available for those in need of joint support.
Developed by GELITA, FORTIGEL® is an innovative ingredient for the regeneration of joint cartilage. Collagenous protein makes up nearly 70% of cartilage mass. Optimized specific collagen peptides of FORTIGEL® have been proven to activate the growth of new cartilage by stimulating cells helping to ease joint discomfort and make the joints smooth and mobile. By keeping people physically active and mobile, FORTIGEL® can improve their quality of life.
FORTIGEL® promotes the growth of cartilage tissue
The effectiveness of FORTIGEL® has been scientifically proven in numerous studies. According to published research, orally administered FORTIGEL® is absorbed intestinally and accumulates in cartilage. The ingestion of FORTIGEL® stimulates a statistically significant increase in cartilage tissue metabolism.
Penn State study confirms improvement of mobility with FORTIGEL®
At Penn State University (USA, 2008), 147 athletes were recruited who experienced activity-related joint pain. Those athletes (mean age 20.1 years) were subdivided into one group taking FORTIGEL® as a nutritional supplement and a control group taking a placebo for 24 weeks. The severity of symptoms was rated both by the treating physician and by the study participants with a visual analogue scale.
In this prospective, randomized, double-blind, placebo-controlled study, it was interesting to observe a statistically significant difference in pain perception between treatment and control groups. When utilizing alternative therapies such as hydrotherapy, massage, and ice and heat packs, there was a clear-cut difference between the treatment and the placebo group in favor of the FORTIGEL® group. This was the first trial to show improvement in joint pain in healthy athletes treated with FORTIGEL®.
In summary, the studies confirm that the intake of FORTIGEL® results in improvement of mobility in healthy individuals.
McAlindon proves the long-term effect of FORTIGEL®
In a study published in March 2011 by McAlindon and colleagues, the long-term effect of FORTIGEL® treatment on the composition of hyaline cartilage in individuals with early knee osteoarthritis was investigated. This prospective, randomized, double-blind, placebo-controlled pilot study was performed at the Tufts Medical Center in cooperation with Harvard University.
A specific type of magnetic resonance imaging (dGEMRIC) was utilized in order to visualize structural changes in the cartilage tissue of the respective study participants. Overall, 30 subjects were randomized into one group receiving 10 g FORTIGEL® a day for 48 weeks and a control group receiving a placebo. Three MRI scans of the knee were performed on each subject, one at baseline, one at 24 weeks with the final scan at 48 weeks.
The analysis of the cartilage scans revealed a statistically significant increase in proteoglycan density in the medial and lateral tibial regions of the FORTIGEL® treated subjects compared to the placebo group. Results indicate that oral supplementation of FORTIGEL® has a direct impact on human cartilage tissue. This confirms previous experimental data and clearly demonstrates that specific orally administered collagen peptides can have an influence on cartilage tissue regeneration. It can be assumed that this observed effect is not limited to pathophysiological conditions, as indicated by additional clinical studies.
• Stimulating bone matrix formation
FORTIGEL ® regenerates cartilage tissue in humans
University of Freiburg, Germany confirms mobility improvement in young adults
The intention of the mono-centric, placebo-controlled, randomized, double-blind, observational trial on 160 subjects at the Institute for Sports and Sports Science, University of Freiburg, Germany was to investigate the effect of orally administered Bioactive Collagen Peptides (BCP®) on young adults suffering from diagnosed activity-related knee joint pain. In the study, a daily dosage of 5 g FORTIGEL® or placebo was orally administered for 12 duration of weeks. After 3, 6, and 12 weeks changes in pain, stiffness, and physical function were evaluated in the FORTIGEL® group using the Western Ontario and McMaster Universities Index score (WOMAC)4.
The results of the study clearly demonstrate the efficacy of a daily intake of 5 g FORTIGEL® in the treatment of gon- and cox-arthritis. After only 3 weeks of oral administration of the product, a statistically significant improvement in pain, stiffness, and physical function could be observed. Moreover, this positive effect of FORTIGEL® persisted and was even more pronounced after 6 and 12 weeks of treatment.
At the same time, secondary treatments such as massage and physiotherapy have been substantially reduced. The increased mobility was accompanied by a statistically significant reduction in stiffness and clear pain relief. In more than 40 % of all patients, a complete pain reduction was achieved and in 70 % a positive effect of the therapy could be demonstrated. Thus FORTIGEL® is an effective therapeutic approach for those suffering from knee- and hip conditions.
FORTIGEL® shows positive pain reduction on main study criteria.
Zdzieblik et al. 2017
FORTIGEL® PRESERVES QUALITY OF LIFE
Based on the presented data it can be concluded that the oral administration of FORTIGEL® has a beneficial effect on cartilage tissue. Consequently, supplementation of FORTIGEL® peptides can contribute to the maintenance of joint health and could help to preserve mobility and quality of life.