FORTIBONE^® – THE MISSING PIECE IN BONE HEALTH MANAGEMENT

Bones need more than calcium
Calcium supplements are everywhere, yet more and more people are suffering from osteoporosis and osteopenia. Bone is a mixture of mineral crystals held in an organic collagen matrix. On their own, the crystals would be extremely brittle and prone to break. Like a bridge is built out of concrete and steel, collagen in the bones is essential for bone flexibility and elasticity. It is important to keep the skeletal system healthy. Osteoporosis (OP) is a condition characterized by low bone mass and micro-architectural deterioration of bone tissue, which leads to enhanced bone fragility and a consequent increase in fracture risk¹. Osteopenia, the early stage of osteoporosis, can begin at the age of 35 years when bone mass progressively declines.² The likelihood to get a fracture increases with age. The risk of contracting a bone fracture is doubling every ten years in both genders.³

FORTIBONE^® stimulates the synthesis of bone collagen matrix
The specific peptides of FORTIBONE^® stimulate bone cells to increase the synthesis of bone components such as collagen. They have a kind of ‘signaling effect’ on osteoblasts to counterbalance the collagen degradation in the extracellular bone matrix, which is the essential framework for bone mineralization. In addition, FORTIBONE^® influences degenerative processes in bones by reducing osteoclast activity. The result is a considerably higher synthesis of collagenous bone matrix.

Bone metabolism

Bone mineral density measurement

Bone mass increase in the spine

Clinically proven to promote bone health
A single-center, prospective, randomized, placebo-controlled, double-blinded study showed the potential of FORTIBONE^®. Over a period of 12 months, 180 women with reduced bone mass participated in a therapy with daily intake of 5 g FORTIBONE^® or placebo. Changes in bone mass density were measured in the spine and femoral neck of the participants detected by DXA scans.

FORTIBONE^® consumption showed a significant improvement of bone density. The results showed a pronounced increase in BMD (Bone Mineral Density) after FORTIBONE^® supplementation in women suffering from osteopenia or osteoporosis. The results indicate an anabolic effect. FORTIBONE^® is an interesting option to counteract bone degeneration.

Changes in bone mineral density

Promising results
The results of this study indicated an anabolic effect, showing a pronounced increase in bone mineral density after FORTIBONE® supplementation. In the femoral neck, BMD increased by 6.7%, whereas in the spine results showed an increase of 3% at the end of the treatment phase. In the same period, bone density in the placebo group decreased by 1.3% in the spine and 1% in the femoral neck. Hence, at the end of the study, subjects in the collagen peptides group showed significantly increased BMD compared to placebo with a 4.2% higher BMD in the spine and a 7.7% higher BMD in the femoral neck.

¹ ALVES RD, DEMMERS JA, BEZSTAROSTI K, VAN DER EERDEN BC, VERHAAR JA, EIJKEN M, VAN LEEUWEN JP (2011) UNRAVELING THE HUMAN BONE MICROENVIRONMENT BEYOND THE CLASSICAL EXTRACELLULAR MATRIX PROTEINS: A HUMAN BONE PROTEIN LIBRARY. J PROTEOME RES 10:4725-4733

² RAISZ LG (2005) PATHOGENESIS OF OSTEOPOROSIS: CONCEPTS, CONFLICTS, AND PROSPECTS.
J CLIN INVEST 115:3318-3325

³ COLE ZA, DENNISON EM, COOPER C (2009) THE IMPACT OF METHODS FOR ESTIMATING BONE HEALTH AND THE GLOBAL BURDEN OF BONE DISEASE. SALUD PUBLICA MEX 51 SUPPL 1:S38-S45

Osteoporosis and Osteopenia are global issues
Bone atrophy, loss of bone density and bone stability is a problem particularly post-menopausal women have to deal with. But not only them. Osteoporosis is a major public health threat for an estimated 44 million U.S. citizens and for 55 % of all Americans 50 years of age and older. Due to the increased human lifespan, osteopenia and osteoporosis have progressively turned into a major worldwide public health problem causing economic costs of € 37 billion in the European Union and $ 20 billion in the United States.*

FORTIBONE^® is developed to promote bone health, increasing bone density and reducing degradation processes. Products including FORTIBONE^® appeal to the elderly and also to physically active consumers interested in maintaining good health.

Risk Category Osteoporosis

*COLE ZA, DENNISON EM, COOPER C (2009) THE IMPACT OF METHODS FOR ESTIMATING BONE HEALTH AND THE GLOBAL BURDEN OF BONE DISEASE. SALUD PUBLICA MEX 51 SUPPL 1:S38-S45

BODYBALANCE^® FOR PERFECT BODY COMPOSITION AND AN ACTIVE LIFESTYLE

BODYBALANCE® has a multi-factorial effect on body toning and muscle maintenance
To retain an optimal body composition and to support an active lifestyle, GELITA has developed BODYBALANCE^®. These highly specialized collagen peptides have been shown to decrease fat mass, increase lean body mass, and provide more muscle strength in combination with resistance training.

BODYBALANCE^® has positive effects on two main components of the human body: lean body mass and fat mass. Lean body mass, also called fat-free mass, comprises mainly muscle mass but also bone mass, connective tissue, and body water.

Muscles are essential for physical activity, stability, and posture, they enable blood circulation and help during the digestion of food. A loss of muscle mass over the course of lifetime means a loss of mobility, which is followed by a loss of independence and a loss of quality of life. In summary, the studies confirm that the intake of BODYBALANCE^® results in the improvement of mobility in healthy individuals.

Zdzieblik D, et al. (2015).
Br J Nutr Oesser, S. et al. (2017). JISSN

LBM & FM - Men 

Muscle Strength - Men

Improved workout results – Significant changes in body composition in female participants performing resistance training and supplementing BODYBALANCE®
In a study with premenopausal women the potential of a daily intake of 15g BODYBALANCE® was investigated. Seventyseven women aged between 18-50 years received 15 g/day BODYBALANCE® or placebo for 12 weeks. The Bioactive Collagen Peptide® supplementation, in combination with resistance training, significantly improved body composition in women, not only by increasing lean body mass, but also by reducing their fat mass. This is an effect not consistently observed for any other source of protein supplementation, particularly in women.

Jendricke P, et al. (2019). nutrients

LBM & FM - Women

Muscle Strength - Women


The BODY PROTEIN mechanism
The exact mechanism of BODYBALANCE^® is still the subject of ongoing research, but current data suggest, that the mode of action is based on the multifactorial impact of Bioactive Collagen Peptides (BCP^®) on various metabolic processes and the overall functional unit of muscle: e.g. muscle and fat metabolism.

Recent investigations revealed, BODYBALANCE^® significantly stimulates the mTOR pathway. The availability and activity of this key protein are essential for protein metabolism. Protein metabolism ensures the balance between protein synthesis and protein degradation. More synthesis than breakdown indicates an anabolic state that builds lean tissues, and a higher breakdown than synthesis indicates a catabolic state that decreases lean tissues.

Moreover, BODYBALANCE^® influences fat metabolism. A sufficient energy supply is mandatory for the proliferation of muscle cells and the synthesis of new muscle tissue. The AMPK enzyme is responsible for the energy transfer in the muscle cells. The stimulation of AMPK leads to an increase in fatty acid metabolism, which provides more energy for the cells and results in a reduction of fat mass. Due to its specific amino acid composition and its excellent bioavailability BODYBALANCE^® stimulates fat and muscle metabolisms, finally leading to an improved body composition. 


BODYBALANCE

® significantly stimulates the mTOR pathway

BODYBALANCE® influences fat metabolism. The AMPK enzyme is responsible for the energy transfer in the muscle cells

 
Studies confirm the efficacy of BODYBALANCE^®
Several randomized, placebo-controlled, double-blinded studies have demonstrated the efficacy and potential of the daily intake of 15 g BODYBALANCE^® in combination with resistance training.

In the latest studies ^2,3, the effect of post-exercise supplementation on lean body mass, fat mass, and muscle strength in combination with resistance training was tested. 114 healthy, physically inactive men, aged 35-60 participated. The primary outcome was to compare 15 g BODYBALANCE^® supplementation with a placebo. Changes in body composition were measured by DXA scans. DXA represents the “Gold Standard” in body composition measurement. Total body scans using DXA give a precise measurement of body composition, including bone mass, lean body mass, and fat mass.

In addition, muscle strength, waist circumference, and various blood parameters were determined. The results of the primary endpoint of the study revealed a statistically significant (p<0.05) increase in lean body mass after BODYBALANCE^® supplementation compared to placebo.

Lean body mass

The positive effect was also reflected in the results of the secondary study criteria. BODYBALANCE^® treatment led to improved muscle strength, a reduction of waist circumference, and a statistically significant fat mass reduction (p<0.05), after collagen peptide intake.

² Zdzieblik, D. et al Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomized controlled trial, doi: 10.1017/80007114515002810, British Journal of Nutrition, 2015

³ Unpublished data 2015 , publication pending

BODYBALNCE^® supports what large target groups want: fitness, shape and power in everyday life
During a research based on focus group discussion conducted 2015 in the US, the UK and Germany, our researchers investigated the mindset of the following three target groups:

- Men and women between 25 and 35 years, user of protein products
Determined, young and ambitious

Young males are interested in muscle gain – for visual effects but also increasing strength. Women are interested in losing weight or shaping and toning. Also the so-called ‘generation fitness’ is convinced that working on its appearance is expected from society. So the physical appearance is by far one of the main drivers!

- Men and women between 40 and 55 years, do exercising occasionally
Overcoming frustration

Men are fighting against ‘the belly’ and loss of masculine shape. Women fight against weight, flab and overall loss of shape and tone – in one word: gravity. Slogans like “50 is the new 40, 40 is the new 30” have positive connotations for this age group – but also pressurize and call for action in a society that values a youthful appearance. With longer living expectations and a natural wish for being attractive and healthy as long as possible, people are motivated to do something for themselves. But often fail due to the trivialities of everyday life.

- Men and women between 60 and 80 years, suffering from age related muscle loss
Light at the end of the tunnel

The level of suffering depends on the overall state and accompanying ailments of the individual. Yet, all people are aware that everyday life chores are getting more difficult to achieve. The majority is aware about cause and effect between their struggling and muscle degradation, yet, blame it on a general side effect of aging.

Consumers are convinced by the BODYBALANCE^® effect
BODYBALANCE^® from GELITA bridges the gap that keeps consumers from reaching their goal by its offer to achieve significant results: it improves body composition and boosts the effect of workout.

• The promise of supplementing BODYBALANCE^® in combination with resistance exercise is immediately understood, fascinates people and mirrors peoples goals.

• BODYBALANCE^® products can be easily integrated into daily routines and support the growth of lean body mass and loss of body fat after just a few weeks. People achieve clear results within a credible time frame (10-12 weeks) and with reasonable investment (2-3 hours resistance training per week).

• After explaining the role of collagen in the human body, consumers are highly interested in the mode of action of BODYBALANCE^® and BODYBALANCE^® products.¹

1 Sachet (15 g) daily.
Do not exceed the recommended daily dose.
Food supplements are not intended to replace a varied and balanced nutrition and a healthy lifestyle.

Keep out of reach of children.
Store under dry conditions at room temperature.
Do not expose to direct sunlight.